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A comparison of successful and failed protein interface designs highlights the challenges of designing buried hydrogen bonds

The accurate design of new protein–protein interactions is a longstanding goal of computational protein design. However, most computationally designed interfaces fail to form experimentally. This investigation compares five previously described successful de novo interface designs with 158 failures....

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Detalles Bibliográficos
Main Authors: Stranges, P Benjamin, Kuhlman, Brian
Formato: Artigo
Idioma:Inglês
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2013
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3575862/
https://ncbi.nlm.nih.gov/pubmed/23139141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2187
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