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Protein sequence optimization with a pairwise decomposable penalty for buried unsatisfied hydrogen bonds

In aqueous solution, polar groups make hydrogen bonds with water, and hence burial of such groups in the interior of a protein is unfavorable unless the loss of hydrogen bonds with water is compensated by formation of new ones with other protein groups. For this reason, buried “unsatisfied” polar gr...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Coventry, Brian, Baker, David
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7971855/
https://ncbi.nlm.nih.gov/pubmed/33684097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1008061
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