Native protein sequences are close to optimal for their structures
How large is the volume of sequence space that is compatible with a given protein structure? Starting from random sequences, low free energy sequences were generated for 108 protein backbone structures by using a Monte Carlo optimization procedure and a free energy function based primarily on Lennar...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27033/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10984534/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.19.10383 |
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