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A comparison of successful and failed protein interface designs highlights the challenges of designing buried hydrogen bonds
The accurate design of new protein–protein interactions is a longstanding goal of computational protein design. However, most computationally designed interfaces fail to form experimentally. This investigation compares five previously described successful de novo interface designs with 158 failures....
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Wiley Subscription Services, Inc., A Wiley Company
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3575862/ https://ncbi.nlm.nih.gov/pubmed/23139141 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2187 |
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