RAG and HMGB1 create a large bend in the 23RSS in the V(D)J recombination synaptic complexes

During V(D)J recombination, recombination activating gene proteins RAG1 and RAG2 generate DNA double strand breaks within a paired complex (PC) containing two complementary recombination signal sequences (RSSs), the 12RSS and 23RSS, which differ in the length of the spacer separating heptamer and no...

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Autori principali: Ciubotaru, Mihai, Trexler, Adam J., Spiridon, Laurentiu N., Surleac, Marius D., Rhoades, Elizabeth, Petrescu, Andrei J., Schatz, David G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2013
Soggetti:
Nucleic Acid Enzymes
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3575807/
https://ncbi.nlm.nih.gov/pubmed/23293004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks1294
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