Impaired synaptic clustering of postsynaptic density proteins and altered signal transmission in hippocampal neurons, and disrupted learning behavior in PDZ1 and PDZ2 ligand binding-deficient PSD-95 knockin mice

BACKGROUND: Postsynaptic density (PSD)-95-like membrane-associated guanylate kinases (PSD-MAGUKs) are scaffold proteins in PSDs that cluster signaling molecules near NMDA receptors. PSD-MAGUKs share a common domain structure, including three PDZ (PDZ1/2/3) domains in their N-terminus. While multiple...

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Detalhes bibliográficos
Main Authors: Nagura, Hitoshi, Ishikawa, Yasuyuki, Kobayashi, Katsunori, Takao, Keizo, Tanaka, Tomo, Nishikawa, Kouki, Tamura, Hideki, Shiosaka, Sadao, Suzuki, Hidenori, Miyakawa, Tsuyoshi, Fujiyoshi, Yoshinori, Doi, Tomoko
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3575367/
https://ncbi.nlm.nih.gov/pubmed/23268962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-6606-5-43
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