Senescence sensitivity of breast cancer cells is defined by positive feedback loop between CIP2A and E2F1

Senescence induction contributes to cancer therapy responses and is crucial for p53-mediated tumor suppression. However, whether p53 inactivation actively suppresses senescence induction has been unclear. Here we demonstrate that E2F1 overexpression, due to p53 or p21 inactivation, promotes expressi...

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Main Authors: Laine, Anni, Sihto, Harri, Come, Christophe, Rosenfeldt, Mathias T., Zwolinska, Aleksandra, Niemelä, Minna, Khanna, Anchit, Chan, Edward K., Kähäri, Veli-Matti, Kellokumpu-Lehtinen, Pirkko-Liisa, Sansom, Owen J., Evan, Gerard I., Junttila, Melissa R., Ryan, Kevin M., Marine, Jean-Christophe, Joensuu, Heikki, Westermarck, Jukka
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3572190/
https://ncbi.nlm.nih.gov/pubmed/23306062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-12-0292
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