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In Vivo Messenger RNA Introduction into the Central Nervous System Using Polyplex Nanomicelle

Messenger RNA (mRNA) introduction is a promising approach to produce therapeutic proteins and peptides without any risk of insertion mutagenesis into the host genome. However, it is difficult to introduce mRNA in vivo mainly because of the instability of mRNA under physiological conditions and its s...

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Detalhes bibliográficos
Main Authors: Uchida, Satoshi, Itaka, Keiji, Uchida, Hirokuni, Hayakawa, Kentaro, Ogata, Toru, Ishii, Takehiko, Fukushima, Shigeto, Osada, Kensuke, Kataoka, Kazunori
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3571986/
https://ncbi.nlm.nih.gov/pubmed/23418537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056220
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