PEGylated Polyplex With Optimized PEG Shielding Enhances Gene Introduction in Lungs by Minimizing Inflammatory Responses

Safety is a critical issue in clinical applications of nonviral gene delivery systems. Safe and effective gene introduction into the lungs was previously achieved using polyplexes from poly(ethyleneglycol) (PEG)-block-polycation [PEG-block-PAsp(DET)] and plasmid DNA (pDNA). Although PEGylated polypl...

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Main Authors: Uchida, Satoshi, Itaka, Keiji, Chen, Qixian, Osada, Kensuke, Ishii, Takehiko, Shibata, Masa-Aki, Harada-Shiba, Mariko, Kataoka, Kazunori
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3369293/
https://ncbi.nlm.nih.gov/pubmed/22334020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.20
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