Enhanced Percolation and Gene Expression in Tumor Hypoxia by PEGylated Polyplex Micelles

In regard to gene vectors for cancer gene therapy, their percolation into the tumor tissue should be essential for successful outcome. Here, we studied the tumor penetrability of nonviral vectors (polyplexes) after incubation with the multicellular tumor spheroid (MCTS) models and intratumoral (i.t....

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Autores principales: Han, Muri, Oba, Makoto, Nishiyama, Nobuhiro, Kano, Mitsunobu R, Kizaka-Kondoh, Shinae, Kataoka, Kazunori
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2009
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835242/
https://ncbi.nlm.nih.gov/pubmed/19471245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.119
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