Enhanced Percolation and Gene Expression in Tumor Hypoxia by PEGylated Polyplex Micelles

In regard to gene vectors for cancer gene therapy, their percolation into the tumor tissue should be essential for successful outcome. Here, we studied the tumor penetrability of nonviral vectors (polyplexes) after incubation with the multicellular tumor spheroid (MCTS) models and intratumoral (i.t....

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Sonraí Bibleagrafaíochta
Main Authors: Han, Muri, Oba, Makoto, Nishiyama, Nobuhiro, Kano, Mitsunobu R, Kizaka-Kondoh, Shinae, Kataoka, Kazunori
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2009
Ábhair:
Original Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835242/
https://ncbi.nlm.nih.gov/pubmed/19471245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.119
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