CD134/CD137 Dual Costimulation-Elicited IFN-γ Maximizes Effector T Cell Function but Limits Treg Expansion

T cell tolerance to tumor antigens represents a major hurdle in generating tumor immunity. Combined administration of agonistic monoclonal antibodies to the costimulatory receptors CD134 plus CD137 can program T cells responding to tolerogenic antigen to undergo expansion and effector T cell differe...

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Main Authors: Rose, Marie-Clare St., Taylor, Roslyn A., Bandyopadhyay, Suman, Qui, Harry Z., Hagymasi, Adam T., Vella, Anthony T., Adler, Adam J.
格式: Artigo
語言:Inglês
出版: 2013
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3570742/
https://ncbi.nlm.nih.gov/pubmed/23295363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/icb.2012.74
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