Self-Antigen Prevents CD8 T Cell Effector Differentiation by CD134 and CD137 Dual Costimulation

We compared how CD4 vs CD8 cells attain the capacity to express the effector cytokine IFN-γ under both immunogenic and tolerogenic conditions. Although the Ifng gene locus was epigenetically repressed in naive Ag-inexperienced CD4 cells, it had already undergone partial remodeling toward a transcrip...

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Hauptverfasser: Bandyopadhyay, Suman, Long, Meixiao, Qui, Harry Z., Hagymasi, Adam T., Slaiby, Aaron M., Mihalyo, Marianne A., Aguila, Hector L., Mittler, Robert S., Vella, Anthony T., Adler, Adam J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846364/
https://ncbi.nlm.nih.gov/pubmed/19017962
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