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Steady State Dendritic Cells Present Parenchymal Self-Antigen and Contribute to, but Are Not Essential for, Tolerization of Naive and Th1 Effector CD4 Cells

Bone marrow-derived APC are critical for both priming effector/memory T cell responses to pathogens and inducing peripheral tolerance in self-reactive T cells. In particular, dendritic cells (DC) can acquire peripheral self-Ags under steady state conditions and are thought to present them to cognate...

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Detalhes bibliográficos
Main Authors: Hagymasi, Adam T., Slaiby, Aaron M., Mihalyo, Marianne A., Qui, Harry Z., Zammit, David J., Lefrançois, Leo, Adler, Adam J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846358/
https://ncbi.nlm.nih.gov/pubmed/17641018
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