CD134 Plus CD137 Dual Costimulation Induces Eomesodermin in CD4 T Cells to Program Cytotoxic Th1 Differentiation

Cytotoxic CD4 Th1 cells are emerging as a therapeutically useful T cell lineage that can effectively target tumors, but until now the pathways that govern their differentiation have been poorly understood. We demonstrate that CD134 (OX40) costimulation programs naive self- and virus-reactive CD4 T c...

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Autori principali: Qui, Harry Z., Hagymasi, Adam T., Bandyopadhyay, Suman, St. Rose, Marie-Clare, Ramanarasimhaiah, Raghunath, Ménoret, Antoine, Mittler, Robert S., Gordon, Scott M., Reiner, Steven L., Vella, Anthony T., Adler, Adam J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3178659/
https://ncbi.nlm.nih.gov/pubmed/21880986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1101244
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