Alzheimer brain-derived Aβ impairs synaptic remodelling and memory consolidation

Aggregation of the amyloid β-protein (Aβ) is believed to play a central role in initiating the molecular cascade that culminates in Alzheimer-type dementia (AD), a disease which in its early stage is characterized by synaptic loss and impairment of episodic memory. Here we show that icv injection of...

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Detalhes bibliográficos
Main Authors: Borlikova, Gilyana G., Trejo, Margarita, Mably, Alexandra J., Mc Donald, Jessica M., Frigerio, Carlo Sala, Regan, Ciaran M., Murphy, Keith J., Masliah, Eliezer, Walsh, Dominic M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3570694/
https://ncbi.nlm.nih.gov/pubmed/23182244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2012.10.028
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