Activating HER2 mutations in HER2 gene amplification negative breast cancer

Data from eight breast cancer genome sequencing projects identified 25 patients with HER2 somatic mutations in cancers lacking HER2 gene amplification. To determine the phenotype of these mutations, we functionally characterized thirteen HER2 mutations using in vitro kinase assays, protein structure...

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Hauptverfasser: Bose, Ron, Kavuri, Shyam M., Searleman, Adam C., Shen, Wei, Shen, Dong, Koboldt, Daniel C., Monsey, John, Goel, Nicholas, Aronson, Adam B., Li, Shunqiang, Ma, Cynthia X., Ding, Li, Mardis, Elaine R., Ellis, Matthew J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3570596/
https://ncbi.nlm.nih.gov/pubmed/23220880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-12-0349
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