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mTORC1 and p53: Clash of the gods?

A balance must be struck between cell growth and stress responses to ensure that cells proliferate without accumulating damaged DNA. This balance means that optimal cell proliferation requires the integration of pro-growth and stress-response pathways. mTOR (mechanistic target of rapamycin) is a ple...

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Autori principali: Hasty, Paul, Sharp, Zelton Dave, Curiel, Tyler J., Campisi, Judith
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3570511/
https://ncbi.nlm.nih.gov/pubmed/23255104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.22912
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