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The Evolutionary History of Amino Acid Variations Mediating Increased Resistance of S. aureus Identifies Reversion Mutations in Metabolic Regulators

The evolution of resistance in Staphylococcus aureus occurs rapidly, and in response to all known antimicrobial treatments. Numerous studies of model species describe compensatory roles of mutations in mediating competitive fitness, and there is growing evidence that these mutation types also drive...

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Detalhes bibliográficos
Main Authors: Champion, Mia D., Gray, Vanessa, Eberhard, Carl, Kumar, Sudhir
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3570469/
https://ncbi.nlm.nih.gov/pubmed/23424663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056466
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