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Performance of computational tools in evaluating the functional impact of laboratory-induced amino acid mutations

Summary: Site-directed mutagenesis is frequently used by scientists to investigate the functional impact of amino acid mutations in the laboratory. Over 10 000 such laboratory-induced mutations have been reported in the UniProt database along with the outcomes of functional assays. Here, we explore...

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Detalhes bibliográficos
Main Authors: Gray, Vanessa E., Kukurba, Kimberly R., Kumar, Sudhir
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413386/
https://ncbi.nlm.nih.gov/pubmed/22685075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/bts336
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