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Evolutionary anatomies of positions and types of disease-associated and neutral amino acid mutations in the human genome

BACKGROUND: Amino acid mutations in a large number of human proteins are known to be associated with heritable genetic disease. These disease-associated mutations (DAMs) are known to occur predominantly in positions essential to the structure and function of the proteins. Here, we examine how the re...

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Detalhes bibliográficos
Main Authors: Subramanian, Sankar, Kumar, Sudhir
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1702542/
https://ncbi.nlm.nih.gov/pubmed/17144929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-7-306
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