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Evolutionary anatomies of positions and types of disease-associated and neutral amino acid mutations in the human genome
BACKGROUND: Amino acid mutations in a large number of human proteins are known to be associated with heritable genetic disease. These disease-associated mutations (DAMs) are known to occur predominantly in positions essential to the structure and function of the proteins. Here, we examine how the re...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
BioMed Central
2006
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1702542/ https://ncbi.nlm.nih.gov/pubmed/17144929 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-7-306 |
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