Assessing the Evolutionary Impact of Amino Acid Mutations in the Human Genome

Quantifying the distribution of fitness effects among newly arising mutations in the human genome is key to resolving important debates in medical and evolutionary genetics. Here, we present a method for inferring this distribution using Single Nucleotide Polymorphism (SNP) data from a population wi...

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Detalhes bibliográficos
Main Authors: Boyko, Adam R., Williamson, Scott H., Indap, Amit R., Degenhardt, Jeremiah D., Hernandez, Ryan D., Lohmueller, Kirk E., Adams, Mark D., Schmidt, Steffen, Sninsky, John J., Sunyaev, Shamil R., White, Thomas J., Nielsen, Rasmus, Clark, Andrew G., Bustamante, Carlos D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2377339/
https://ncbi.nlm.nih.gov/pubmed/18516229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000083
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