Proportionally More Deleterious Genetic Variation In European than in African Populations

Quantifying the number of deleterious mutations per diploid human genome is of critical concern to both evolutionary and medical geneticists1–3. Here, we combine genome-wide polymorphism data from PCR-based exon re-sequencing, comparative genomic data across mammalian species, and protein structure...

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Detalhes bibliográficos
Main Authors: Lohmueller, Kirk E., Indap, Amit R., Schmidt, Steffen, Boyko, Adam R., Hernandez, Ryan D., Hubisz, Melissa J., Sninsky, John J., White, Thomas J., Sunyaev, Shamil R., Nielsen, Rasmus, Clark, Andrew G., Bustamante, Carlos D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923434/
https://ncbi.nlm.nih.gov/pubmed/18288194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature06611
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