Proportionally More Deleterious Genetic Variation In European than in African Populations

Quantifying the number of deleterious mutations per diploid human genome is of critical concern to both evolutionary and medical geneticists1–3. Here, we combine genome-wide polymorphism data from PCR-based exon re-sequencing, comparative genomic data across mammalian species, and protein structure...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Lohmueller, Kirk E., Indap, Amit R., Schmidt, Steffen, Boyko, Adam R., Hernandez, Ryan D., Hubisz, Melissa J., Sninsky, John J., White, Thomas J., Sunyaev, Shamil R., Nielsen, Rasmus, Clark, Andrew G., Bustamante, Carlos D.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2008
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923434/
https://ncbi.nlm.nih.gov/pubmed/18288194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature06611
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