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Impact of deleterious passenger mutations on cancer progression

Cancer progression is driven by the accumulation of a small number of genetic alterations. However, these few driver alterations reside in a cancer genome alongside tens of thousands of additional mutations termed passengers. Passengers are widely believed to have no role in cancer, yet many passeng...

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Detalhes bibliográficos
Main Authors: McFarland, Christopher D., Korolev, Kirill S., Kryukov, Gregory V., Sunyaev, Shamil R., Mirny, Leonid A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581883/
https://ncbi.nlm.nih.gov/pubmed/23388632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1213968110
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