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Accumulation of Deleterious Passenger Mutations Is Associated with the Progression of Hepatocellular Carcinoma

In hepatocellular carcinoma (HCC), somatic genome-wide DNA mutations are numerous, universal and heterogeneous. Some of these somatic mutations are drivers of the malignant process but the vast majority are passenger mutations. These passenger mutations can be deleterious to individual protein funct...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Budzinska, Magdalena A., Tu, Thomas, d’Avigdor, William M. H., McCaughan, Geoffrey W., Luciani, Fabio, Shackel, Nicholas A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5025244/
https://ncbi.nlm.nih.gov/pubmed/27631787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0162586
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