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Accumulation of Deleterious Passenger Mutations Is Associated with the Progression of Hepatocellular Carcinoma
In hepatocellular carcinoma (HCC), somatic genome-wide DNA mutations are numerous, universal and heterogeneous. Some of these somatic mutations are drivers of the malignant process but the vast majority are passenger mutations. These passenger mutations can be deleterious to individual protein funct...
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Publicado no: | PLoS One |
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Main Authors: | , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Public Library of Science
2016
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5025244/ https://ncbi.nlm.nih.gov/pubmed/27631787 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0162586 |
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