The damaging effect of passenger mutations on cancer progression

Genomic instability and high mutation rates cause cancer to acquire numerous mutations and chromosomal alterations during its somatic evolution, most are termed passengers because they do not confer cancer phenotypes. Evolutionary simulations and cancer genomic studies suggest that mildly deleteriou...

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Detaylı Bibliyografya
Yayımlandı:Cancer Res
Asıl Yazarlar: McFarland, Christopher D, Yaglom, Julia A, Wojtkowiak, Jonathan W, Scott, Jacob G, Morse, David L, Sherman, Michael Y, Mirny, Leonid A
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5639691/
https://ncbi.nlm.nih.gov/pubmed/28536279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-3283-T
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