Assessing the Evolutionary Impact of Amino Acid Mutations in the Human Genome

Quantifying the distribution of fitness effects among newly arising mutations in the human genome is key to resolving important debates in medical and evolutionary genetics. Here, we present a method for inferring this distribution using Single Nucleotide Polymorphism (SNP) data from a population wi...

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Bibliographic Details
Main Authors: Boyko, Adam R., Williamson, Scott H., Indap, Amit R., Degenhardt, Jeremiah D., Hernandez, Ryan D., Lohmueller, Kirk E., Adams, Mark D., Schmidt, Steffen, Sninsky, John J., Sunyaev, Shamil R., White, Thomas J., Nielsen, Rasmus, Clark, Andrew G., Bustamante, Carlos D.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2008
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2377339/
https://ncbi.nlm.nih.gov/pubmed/18516229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000083
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