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Evolutionary Balancing Is Critical for Correctly Forecasting Disease-Associated Amino Acid Variants
Computational predictions have become indispensable for evaluating the disease-related impact of nonsynonymous single-nucleotide variants discovered in exome sequencing. Many such methods have their roots in molecular evolution, as they use information derived from multiple sequence alignments. We s...
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| Main Authors: | , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3649672/ https://ncbi.nlm.nih.gov/pubmed/23462317 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/mst037 |
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