Control of TMEM16A by INO-4995 and other inositolphosphates

BACKGROUND AND PURPOSE: Ca(2+)-dependent Cl(−) secretion (CaCC) in airways and other tissues is due to activation of the Cl(−) channel TMEM16A (anoctamin 1). Earlier studies suggested that Ca(2+)-activated Cl(−) channels are regulated by membrane lipid inositol phosphates, and that 1-O-octyl-2-O-but...

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Detalhes bibliográficos
Main Authors: Tian, Yuemin, Schreiber, Rainer, Wanitchakool, Podchanart, Kongsuphol, Patthara, Sousa, Marisa, Uliyakina, Inna, Palma, Marta, Faria, Diana, Traynor-Kaplan, Alexis E, Fragata, José I, Amaral, Margarida D, Kunzelmann, Karl
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3570019/
https://ncbi.nlm.nih.gov/pubmed/22946960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.02193.x
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