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Regulation of TMEM16A/ANO1 and TMEM16F/ANO6 ion currents and phospholipid scrambling by Ca(2+) and plasma membrane lipid

KEY POINTS: TMEM16 proteins can operate as Ca(2+)‐activated Cl(−) channels or scramble membrane phospholipids, which are both highly relevant mechanisms during disease. Overexpression of TMEM16A and TMEM16F were found to be partially active at 37°C and at resting intracellular Ca(2+) concentrations....

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Detalhes bibliográficos
Publicado no:J Physiol
Main Authors: Schreiber, Rainer, Ousingsawat, Jiraporn, Wanitchakool, Podchanart, Sirianant, Lalida, Benedetto, Roberta, Reiss, Karina, Kunzelmann, Karl
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5767690/
https://ncbi.nlm.nih.gov/pubmed/29134661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP275175
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