Deletion of Iron Regulatory Protein 1 Causes Polycythemia and Pulmonary Hypertension in Mice through Translational De-repression of HIF2α

Iron regulatory proteins 1 and 2 (Irps) post-transcriptionally control the expression of transcripts that contain iron responsive element (IRE) sequences, including ferritin, ferroportin, transferrin receptor and hypoxia inducible factor 2α (HIF2α). We report here that mice with targeted deletion of...

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Main Authors: Ghosh, Manik C., Zhang, De-Liang, Jeong, Suh Young, Kovtunovych, Gennadiy, Ollivierre-Wilson, Hayden, Noguchi, Audrey, Tu, Tiffany, Senecal, Thomas, Robinson, Gabrielle, Crooks, Daniel R., Tong, Wing-Hang, Ramaswamy, Kavitha, Singh, Anamika, Graham, Brian B., Tuder, Rubin M., Yu, Zu-Xi, Eckhaus, Michael, Lee, Jaekwon, Springer, Danielle A., Rouault, Tracey A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2013
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3569856/
https://ncbi.nlm.nih.gov/pubmed/23395173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2012.12.016
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