Deletion of Iron Regulatory Protein 1 Causes Polycythemia and Pulmonary Hypertension in Mice through Translational De-repression of HIF2α

Iron regulatory proteins 1 and 2 (Irps) post-transcriptionally control the expression of transcripts that contain iron responsive element (IRE) sequences, including ferritin, ferroportin, transferrin receptor and hypoxia inducible factor 2α (HIF2α). We report here that mice with targeted deletion of...

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Detaylı Bibliyografya
Asıl Yazarlar: Ghosh, Manik C., Zhang, De-Liang, Jeong, Suh Young, Kovtunovych, Gennadiy, Ollivierre-Wilson, Hayden, Noguchi, Audrey, Tu, Tiffany, Senecal, Thomas, Robinson, Gabrielle, Crooks, Daniel R., Tong, Wing-Hang, Ramaswamy, Kavitha, Singh, Anamika, Graham, Brian B., Tuder, Rubin M., Yu, Zu-Xi, Eckhaus, Michael, Lee, Jaekwon, Springer, Danielle A., Rouault, Tracey A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3569856/
https://ncbi.nlm.nih.gov/pubmed/23395173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2012.12.016
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