Artemis and p53 cooperate to suppress oncogenic N-myc amplification in progenitor B cells

The nonhomologous DNA end-joining (NHEJ) pathway contains six known components, including Artemis, a nuclease mutated in a subset of human severe combined immunodeficient patients. Mice doubly deficient for the five previously analyzed NHEJ factors and p53 inevitably develop progenitor B lymphomas h...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Rooney, Sean, Sekiguchi, JoAnn, Whitlow, Scott, Eckersdorff, Mark, Manis, John P., Lee, Charles, Ferguson, David O., Alt, Frederick W.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC356964/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14983023/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0308757101
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