PRT-060318, a novel Syk inhibitor, prevents heparin-induced thrombocytopenia and thrombosis in a transgenic mouse model

Heparin-induced thrombocytopenia (HIT) is a major cause of morbidity and mortality resulting from the associated thrombosis. Extensive studies using our transgenic mouse model of HIT have shown that antibodies reactive with heparin-platelet factor 4 complexes lead to FcγRIIA-mediated platelet activa...

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Autors principals: Reilly, Michael P., Sinha, Uma, André, Pierrette, Taylor, Scott M., Pak, Yvonne, DeGuzman, Francis R., Nanda, Nisha, Pandey, Anjali, Stolla, Moritz, Bergmeier, Wolfgang, McKenzie, Steven E.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2011
Matèries:
Platelets and Thrombopoiesis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568699/
https://ncbi.nlm.nih.gov/pubmed/21088136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-03-274969
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