The Potential for Isocitrate Dehydrogenase Mutations to Produce 2-Hydroxyglutarate Depends on Allele Specificity and Subcellular Compartmentalization

Monoallelic point mutations in cytosolic isocitrate dehydrogenase 1 (IDH1) and its mitochondrial homolog IDH2 can lead to elevated levels of 2-hydroxyglutarate (2HG) in multiple cancers. Here we report that cellular 2HG production from cytosolic IDH1 mutation is dependent on the activity of a retain...

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Bibliografiske detaljer
Main Authors: Ward, Patrick S., Lu, Chao, Cross, Justin R., Abdel-Wahab, Omar, Levine, Ross L., Schwartz, Gary K., Thompson, Craig B.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2013
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567635/
https://ncbi.nlm.nih.gov/pubmed/23264629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.435495
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