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Calcium Binding by Synaptotagmin's C(2)A Domain is an Essential Element of the Electrostatic Switch That Triggers Synchronous Synaptic Transmission
Synaptotagmin is the major calcium sensor for fast synaptic transmission that requires the synchronous fusion of synaptic vesicles. Synaptotagmin contains two calcium-binding domains: C(2)A and C(2)B. Mutation of a positively charged residue (R233Q in rat) showed that Ca(2+)-dependent interactions b...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Society for Neuroscience
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3567453/ https://ncbi.nlm.nih.gov/pubmed/22279210 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4652-11.2012 |
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