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A Conformational Switch in Complexin is Required for Synaptotagmin to Trigger Synaptic Fusion
The crystal structure of Complexin bound to a pre-fusion SNAREpin mimetic shows that the accessory helix extends away from the SNAREpin in an “open” conformation, binding another SNAREpin, and inhibiting its assembly to clamp fusion. In contrast, the accessory helix in the post-fusion complex parall...
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| Autori principali: | , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3668341/ https://ncbi.nlm.nih.gov/pubmed/21785412 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2103 |
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