A Conformational Switch in Complexin is Required for Synaptotagmin to Trigger Synaptic Fusion

The crystal structure of Complexin bound to a pre-fusion SNAREpin mimetic shows that the accessory helix extends away from the SNAREpin in an “open” conformation, binding another SNAREpin, and inhibiting its assembly to clamp fusion. In contrast, the accessory helix in the post-fusion complex parall...

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Main Authors: Krishnakumar, Shyam S., Radoff, Daniel T., Kümmel, Daniel, Giraudo, Claudio G., Li, Feng, Khandan, Lavan, Baguley, Stephanie, Coleman, Jeff, Reinisch, Karin M., Pincet, Frederic, Rothman, James E.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668341/
https://ncbi.nlm.nih.gov/pubmed/21785412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2103
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