Re-visiting the trans insertion model for complexin clamping

We have previously proposed that complexin cross-links multiple pre-fusion SNARE complexes via a trans interaction to function as a clamp on SNARE-mediated neurotransmitter release. A recent NMR study was unable to detect the trans clamping interaction of complexin and therefore questioned the previ...

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Pubblicato in:eLife
Autori principali: Krishnakumar, Shyam S, Li, Feng, Coleman, Jeff, Schauder, Curtis M, Kümmel, Daniel, Pincet, Frederic, Rothman, James E, Reinisch, Karin M
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2015
Soggetti:
Biochemistry
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4384536/
https://ncbi.nlm.nih.gov/pubmed/25831964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.04463
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