Membrane Penetration by Synaptotagmin Is Required for Coupling Calcium Binding to Vesicle Fusion In Vivo

The vesicle protein synaptotagmin I is the Ca(2+) sensor that triggers fast, synchronous release of neurotransmitter. Specifically, Ca(2+) binding by the C(2)B domain of synaptotagmin is required at intact synapses, yet the mechanism whereby Ca(2+) binding results in vesicle fusion remains controver...

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Main Authors: Paddock, Brie E., Wang, Zhao, Biela, Laurie M., Chen, Kaiyun, Getzy, Michael D., Striegel, Amelia, Richmond, Janet E., Chapman, Edwin R., Featherstone, David E., Reist, Noreen E.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3092483/
https://ncbi.nlm.nih.gov/pubmed/21307261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3153-09.2011
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