Calcium Binding by Synaptotagmin's C(2)A Domain is an Essential Element of the Electrostatic Switch That Triggers Synchronous Synaptic Transmission

Synaptotagmin is the major calcium sensor for fast synaptic transmission that requires the synchronous fusion of synaptic vesicles. Synaptotagmin contains two calcium-binding domains: C(2)A and C(2)B. Mutation of a positively charged residue (R233Q in rat) showed that Ca(2+)-dependent interactions b...

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Main Authors: Striegel, Amelia R., Biela, Laurie M., Evans, Chantell S., Wang, Zhao, Delehoy, Jillian B., Sutton, R. Bryan, Chapman, Edwin R., Reist, Noreen E.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567453/
https://ncbi.nlm.nih.gov/pubmed/22279210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4652-11.2012
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