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Ca(2+)-Dependent, Phospholipid-Binding Residues of Synaptotagmin Are Critical for Excitation–Secretion Coupling In Vivo
Synaptotagmin I is the Ca(2+) sensor for fast, synchronous release of neurotransmitter; however, the molecular interactions that couple Ca(2+) binding to membrane fusion remain unclear. The structure of synaptotagmin is dominated by two C(2) domains that interact with negatively charged membranes af...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Society for Neuroscience
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2949296/ https://ncbi.nlm.nih.gov/pubmed/18650324 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0197-08.2008 |
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