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Synaptotagmin C2B Domain Regulates Ca(2+)-triggered Fusion in Vitro: CRITICAL RESIDUES REVEALED BY SCANNING ALANINE MUTAGENESIS
Synaptotagmin (syt) 1 is localized to synaptic vesicles, binds Ca(2+), and regulates neuronal exocytosis. Syt 1 harbors two Ca(2+)-binding motifs referred to as C2A and C2B. In this study we examine the function of the isolated C2 domains of Syt 1 using a reconstituted, SNARE (soluble N-ethylmaleimi...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2581593/ https://ncbi.nlm.nih.gov/pubmed/18784080 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803355200 |
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