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Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca(2+)

Neuronal communication is mediated by Ca(2+)-triggered fusion of transmitter-filled synaptic vesicles with the presynaptic plasma membrane. Synaptotagmin I functions as a Ca(2+) sensor that regulates exocytosis, whereas soluble N-ethylmaleimide–sensitive factor attachment protein (SNAP) receptor (SN...

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Bibliografiske detaljer
Main Authors: Chicka, Michael C, Hui, Enfu, Liu, Huisheng, Chapman, Edwin R
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570314/
https://ncbi.nlm.nih.gov/pubmed/18622390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1463
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