Genome-Wide Functional and Stress Response Profiling Reveals Toxic Mechanism and Genes Required for Tolerance to Benzo[a]pyrene in S. cerevisiae

Benzo[a]pyrene (BaP) is a ubiquitous, potent, and complete carcinogen resulting from incomplete organic combustion. BaP can form DNA adducts but other mechanisms may play a role in toxicity. We used a functional toxicology approach in S. cerevisiae to assess the genetic requirements for cellular res...

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Hlavní autoři: O’Connor, Sean Timothy Francis, Lan, Jiaqi, North, Matthew, Loguinov, Alexandre, Zhang, Luoping, Smith, Martyn T., Gu, April Z., Vulpe, Chris
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2013
Témata:
Genetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567348/
https://ncbi.nlm.nih.gov/pubmed/23403841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2012.00316
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