Genome-Wide CRISPR Screening Identifies the Tumor Suppressor Candidate OVCA2 As a Determinant of Tolerance to Acetaldehyde

Acetaldehyde, a metabolite of ethanol, is a cellular toxicant and a human carcinogen. A genome-wide CRISPR-based loss-of-function screen in erythroleukemic K562 cells revealed candidate genetic contributors affecting acetaldehyde cytotoxicity. Secondary screening exposing cells to a lower acetaldehy...

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Detalhes bibliográficos
Publicado no:Toxicol Sci
Main Authors: Sobh, Amin, Loguinov, Alex, Stornetta, Alessia, Balbo, Silvia, Tagmount, Abderrahmane, Zhang, Luoping, Vulpe, Chris D
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Crispr Screening and Acetaldehyde Tolerance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6484886/
https://ncbi.nlm.nih.gov/pubmed/31059574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfz037
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