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Genome-Wide Functional and Stress Response Profiling Reveals Toxic Mechanism and Genes Required for Tolerance to Benzo[a]pyrene in S. cerevisiae
Benzo[a]pyrene (BaP) is a ubiquitous, potent, and complete carcinogen resulting from incomplete organic combustion. BaP can form DNA adducts but other mechanisms may play a role in toxicity. We used a functional toxicology approach in S. cerevisiae to assess the genetic requirements for cellular res...
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Main Authors: | , , , , , , , |
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Format: | Artigo |
Sprog: | Inglês |
Udgivet: |
Frontiers Media S.A.
2013
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Fag: | |
Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3567348/ https://ncbi.nlm.nih.gov/pubmed/23403841 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2012.00316 |
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