Asymmetric synthesis of host-directed inhibitors of myxoviruses

High-throughput screening (HTS) previously identified benzimidazole 1 (JMN3-003) as a compound with broad antiviral activity against different influenza viruses and paramyxovirus strains. In pursuit of a lead compound from this series for development, we sought to increase both the potency and the a...

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Autors principals: Moore, Terry W, Sana, Kasinath, Yan, Dan, Thepchatri, Pahk, Ndungu, John M, Saindane, Manohar T, Lockwood, Mark A, Natchus, Michael G, Liotta, Dennis C, Plemper, Richard K, Snyder, James P, Sun, Aiming
Format: Artigo
Idioma:Inglês
Publicat: Beilstein-Institut 2013
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Full Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3566758/
https://ncbi.nlm.nih.gov/pubmed/23400228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.9.23
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