Asymmetric synthesis of host-directed inhibitors of myxoviruses

High-throughput screening (HTS) previously identified benzimidazole 1 (JMN3-003) as a compound with broad antiviral activity against different influenza viruses and paramyxovirus strains. In pursuit of a lead compound from this series for development, we sought to increase both the potency and the a...

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Bibliografiske detaljer
Main Authors: Moore, Terry W, Sana, Kasinath, Yan, Dan, Thepchatri, Pahk, Ndungu, John M, Saindane, Manohar T, Lockwood, Mark A, Natchus, Michael G, Liotta, Dennis C, Plemper, Richard K, Snyder, James P, Sun, Aiming
Format: Artigo
Sprog:Inglês
Udgivet: Beilstein-Institut 2013
Fag:
Full Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3566758/
https://ncbi.nlm.nih.gov/pubmed/23400228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.9.23
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