Asymmetric synthesis of host-directed inhibitors of myxoviruses

High-throughput screening (HTS) previously identified benzimidazole 1 (JMN3-003) as a compound with broad antiviral activity against different influenza viruses and paramyxovirus strains. In pursuit of a lead compound from this series for development, we sought to increase both the potency and the a...

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Detalhes bibliográficos
Main Authors: Moore, Terry W, Sana, Kasinath, Yan, Dan, Thepchatri, Pahk, Ndungu, John M, Saindane, Manohar T, Lockwood, Mark A, Natchus, Michael G, Liotta, Dennis C, Plemper, Richard K, Snyder, James P, Sun, Aiming
Formato: Artigo
Idioma:Inglês
Publicado em: Beilstein-Institut 2013
Assuntos:
Full Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3566758/
https://ncbi.nlm.nih.gov/pubmed/23400228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.9.23
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